ICPi: immune checkpoint inhibitors; HCC: hepatocellular carcinoma; RCC: renal cell carcinoma; ACTH: adrenocorticotropic hormone; NSCLC: non-small cell lung cancer; NR: not reported; ICI-HP: immune checkpoint inhibitor-induced hypopituitarism. This evidence concerns the gene POMC and hereditary clear cell renal cell carcinoma.