AKT1 and neoplasm: Gene set enrichment analysis (GSEA) of our previously published RNA sequencing (RNA-Seq) data revealed significant activation of MAPK, PI3K-Akt, and FoxO pathways in oHSV-infected GBM12 and MDA-MB-468 cells (Fig. 1E, Fig. S4A-B), suggesting that while HSV-1 exploits these cascades for replication, they also drive tumor regrowth and immune evasion.8