MYC and neoplasm: To better understand the sex bias driving tumor prevalence and prognosis, we developed an immune-competent C57BL/6J mouse model of G3-like MB by intracerebellar injection of lentivirus overexpressing a phosphomimetic c-MYC S62D mutant (pLenti-MYCS62D), which replicates the high frequency of serine 62 phosphorylation observed in human G3 MBs17 (Fig. 1f and Extended Data Fig. 2a-f).