MYC and Granuloma: The mTORC1 observation aligns with experimental findings showing that chronic mTORC1 activation in macrophages drives granuloma formation and proinflammatory remodeling, providing a mechanistic link between our proteomic signature and persistent granulomatous inflammation.29 Furthermore, the MYC transcription factor, involved in cell proliferation and growth, has also been associated with greater formation of multinuclear macrophage subsets that comprise granulomas.30