Responses to cytokines promoting T cell function (IL-1-β, IL-2, IL-7, IL-15, IFN-α1, IFN-β, IFN-ω, IFN-γ) were downregulated in T cell aggregates relative to the tumor core, macrophage and DC islands but upregulated compared to other niches. The gene discussed is IL15; the disease is neoplasm.