RAC1 and acute myeloid leukemia: Furthermore, Rac GTPases (Rac1, 2, and 3), a subfamily of the Rho GTPases (Fig. 1), have been proposed as significant drivers in the pathophysiology of AML and have been linked to shorter overall survival., GGPP has also been reported as a pivotal metabolite for the activation of signaling by oncogenic KRAS mutants for various hematological malignancies, including AML, and MM.