Compared with those in the sham livers (calculated based on the total# of cells isolated from IR livers and percentages of KCs), KCs were significantly depleted by liver IR: 90m ischemia resulted in more than 95% reduction, while 60m ischemia resulted in ~ 70% reduction, with simultaneous increases of infiltrating inflammatory myeloid cells (CD11bhighGr-1+) at 1500% and 500%, respectively (Fig. 1A, B). Here, TBCE is linked to digestive system neoplasm.