PLEKHG7 and neoplasm: C12orf74 has been identified as a novel oncogene that is upregulated in lung adenocarcinoma and cervical cancer, where it promotes tumor proliferation and metastasis through activation of the EGFR/AKT/mTORC1 signaling pathway and is associated with poor prognosis, particularly in HPV-positive cervical tumors due to promoter hypomethylation63; in addition, C12orf74 has been linked to reduced coronary artery disease risk64.