EPHB1 is a receptor tyrosine kinase involved in neural development, including axon guidance at the optic chiasm for proper retinal ganglion cell projection56, as well as immune cell maturation and cell migration57,58; its reduced expression is linked to increased tumor invasiveness and poor prognosis in colorectal, gastric, ovarian, and brain cancers59–61, with additional associations to chronic muscle pain62. This evidence concerns the gene NTRK1 and neoplasm.