Interestingly, the large CPD formation enhancement at position 3/4 in ETS binding sites also had significantly reduced repair (z-score=4.24, Fig. 4e), suggesting that a combination of TF-induced CPD formation followed by TF-inhibited repair are collectively driving the exceptional skin cancer mutation enrichment at ETS positions 3 and 4 in skin cancer. This evidence concerns the gene TF and skin cancer.