Tioconazole (TCZ), an antifungal drug, is able to occupy the active sites of autophagy-related proteases autophagy related 4A (ATG4A) or autophagy related 4B (ATG4B), and directly block their enzymatic activity 58, thus diminishing autophagic flux in cancer cells under stress conditions 58. The gene discussed is ATG4A; the disease is cancer.