The TCZ/UU-T02 combination showed more tumor suppression efficiency in SH-SY5Y xenografts compared to monotherapies, significantly inhibiting tumor volume, mass, proliferative activity (Ki-67 index), and angiogenesis (CD31+ vessels), with no obvious toxicity in the heart, liver, or kidney of nude mice models (Figure 7F, G and Figure S12E, F). This evidence concerns the gene PECAM1 and neoplasm.