Compared with either pioglitazone or GlcCer treatment alone, the combination treatment significantly increased Drd2 levels in the dorsal striatum of mice after CRS (Figure 6G); chromatin immunoprecipitation (ChIP) also revealed greater enrichment of PPARγ at the Drd2 promoter induced by combination treatment than treatment of pioglitazone or GlcCer alone (Figure 6H, I). The gene discussed is PPARG; the disease is congenital rubella syndrome.