Altered expression and function of inhibitory GABAAR subunits (α1-3), excitatory N-methyl-D-aspartate receptor (NMDAR) subunits (GluN1, GluN2A, GluN2B), and AMPAR subunits (GluA1, GluA2) have been demonstrated to be associated with E/I imbalance in epilepsy 47, 48. The gene discussed is GRIN2B; the disease is epilepsy.