HNF1B and autosomal dominant polycystic kidney disease: For example, although it is recognized that ADPKD can present prenatally, it is most often expected to present in adulthood and therefore may not be considered a likely diagnosis when considering the differential for fetuses with CyKD on imaging.30, 31, 32, 33 However, more than half of positive findings in fetuses in this cohort (55.6%, n = 5/9) were due to variants in PKD1 and HNF1B, genes responsible for autosomal dominant forms of CyKD.