Positive results were identified in nine different genes exclusively offered on the Cystic Kidney Disease Panel (INVS, NPHP1, NPHP3, NPHP4, OFD1, PAX2, UMOD, VHL, and WDR19); these results represented 4.6% (28/610) of the total positive reports. The gene discussed is NPHP4; the disease is cystic kidney disease.