Consistent with a broader tumor-adipose axis, exosomes carrying heat shock proteins HSP70 and HSP90 aggravated cachexia by inducing lipolysis and muscle atrophy, whereas the pharmacologic blockade of exosome biogenesis (neutral sphingomyelinase inhibitor GW4869) blunted WAT browning and mitigated cachexia in vivo [102]. Here, SMPD2 is linked to neoplasm.