A recent study extending this axis demonstrated that Zfp423 deletion reactivated EBF2 in mice, upregulated adipocyte thermogenesis, and reduced obesity caused by high-fat diets consumed during the light-inactive period by enhancing phosphocreatine-creatine cycling, during which ATP synthesis takes place [76]. Here, ZNF423 is linked to obesity due to melanocortin 4 receptor deficiency.