Inhibition of mTOR with rapamycin or simultaneous genetic deletion of both insulin and insulin growth factor 1 (Igf1) receptors alleviated RPS6 hyperphosphorylation, mitigated renal disease, and extended lifespan, suggesting that altered metabolic signaling plays a significant role in glomerular disease development and progression.16 The gene discussed is MTOR; the disease is glomerular disorder.