In line with these functional data, we also observed that GDM exposure increased the protein levels of cardiac hypertrophy markers (ANP, BNP, and MYH7) and exacerbated TAC-induced cardiac hypertrophy, as evidenced by an increased HW/BW ratio, larger cardiomyocyte size, and greater cardiac fibrosis. The gene discussed is NPPA; the disease is gestational diabetes.