Emerging evidence indicates that metabolic stressors present in GDM (hyperglycemia, hyperinsulinemia, and oxidative stress) can modulate FTO and other m6A regulators in a context-dependent manner; in some cellular systems, high glucose increases FTO, whereas in others oxidative stress or diabetic conditions are associated with reduced FTO activity, linking metabolic disturbance to m6A dysregulation.39 The gene discussed is FTO; the disease is Hyperglycemia.