FTO and Hyperinsulinemia: Emerging evidence indicates that metabolic stressors present in GDM (hyperglycemia, hyperinsulinemia, and oxidative stress) can modulate FTO and other m6A regulators in a context-dependent manner; in some cellular systems, high glucose increases FTO, whereas in others oxidative stress or diabetic conditions are associated with reduced FTO activity, linking metabolic disturbance to m6A dysregulation.39