Importantly, we observed concordant in vivo effects in an intraperitoneal infection model: 4′HAP improved survival, mitigated infection-associated weight loss and water-intake decline, reduced splenomegaly, and lowered ocular parasite burden, while likewise decreasing HIF-1α/VEGF and normalizing GSK3β signaling (Figure 8). The gene discussed is VEGFA; the disease is infection.