ACAN and coronary artery disorder: By setting OR > 1.2 to identify genes significantly positively correlated with CHD, we found that 17 genes—ACAN, CBS, DCTPP1, DTYMK, EDIL3, ELN, F2, IFIT3, ITGB5, ITGB7, NFKB1, PCSK9, PTH1R, SLA2, SORBS1, SPINT3, and TINAGL1—were significantly associated with an increased risk of CHD (Figure 2).