By setting OR > 1.2 to identify genes significantly positively correlated with CHD, we found that 17 genes—ACAN, CBS, DCTPP1, DTYMK, EDIL3, ELN, F2, IFIT3, ITGB5, ITGB7, NFKB1, PCSK9, PTH1R, SLA2, SORBS1, SPINT3, and TINAGL1—were significantly associated with an increased risk of CHD (Figure 2). The gene discussed is ITGB5; the disease is coronary artery disorder.