MXRA5 and open-angle glaucoma: Among the 20 most significant DEGs in TM, three genes fell within 250 kb of a POAG variant: MXRA5 (near rs12846405, POAG variant),35LTBP2 (near rs754458, IOP, POAG and MTAG variant)35,36, and TRNP1 (near 13049669, POAG variant)35 (Table 2).