MYOC and open-angle glaucoma: FAM105A was a DEG in SCE at the 2-day time point only, and this gene is near POAG and IOP associated-variants.35,37,38GPM6B and RASL11B were DEGs for the 2-day SCE time point, and RASL11B was also a DEG for the 1-hour SCE time point; both genes are in known POAG loci.38,48 Myocilin (MYOC) is a gene that has been implicated in early onset glaucoma and POAG,35–37 and it was differentially expressed in TM cells (P adjusted = 4.35 × 10−6) in our study in response to GC.