Variants in LTBP2 have been associated with both IOP and POAG.35,37TRNP1 and MXRA5 were DEGs for both TM and SCE at the 2-day exposure time point and both are near POAG associated variants in a large GWAS study.35 In addition, MXRA5 was a DEG at the 6-hour time point in TM cells. The gene discussed is MXRA5; the disease is open-angle glaucoma.