MAPT and Alzheimer disease: Several amyloid and tau mutant mouse strains have been shown to exhibit sleep disruption and increased wakefulness consistent with human AD (Holth et al., 2017; Huitron-Resendiz et al., 2002; Jyoti et al., 2015; Kang et al., 2009; Platt et al., 2011; Roh et al., 2012; Schneider et al., 2014; Wisor et al., 2005; Bin Zhang et al., 2005; Zhu et al., 2018).