While MAPT mutations are more common in Frontotemporal Dementia, several missense App mutations have been associated with elevated risk for familial or Early-Onset Alzheimer’s Disease (EOAD) (Carter et al., 1992; Chartier-Harlin et al., 1991; Clark et al., 1998; Goate et al., 1991; Hutton et al., 1998). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.