AppNL-G-F mice express humanized APP, exhibit a progressive increase in the accumulation of Aβ, a higher ratio of Aβ42 to Aβ40, amyloidosis, and neuroinflammation in several brain areas (Saito et al., 2014) and thus provide numerous advantages over other murine models that overexpress App. The gene discussed is APP; the disease is amyloidosis.