DMXL2 and early-infantile DEE: Mutations in subunits of the mRAVE complex cause similar neurodevelopmental phenotypes, exemplified by DMXL2 mutations in Ohtahara syndrome (Esposito et al., 2019) and ROGDI mutations in Kohlschutter-Tonz Syndrome (Mory et al., 2012; Schossig et al., 2012).