To evaluate whether the TFs identified to be changed between the control vs IK1-induced GRN reflects defining regulatory factors in IKZF1-mutated B-ALL, we analyzed RNA-seq and ATAC-seq data from a panel of IKZF1-wild-type (WT) and IKZF1-mutated (IK6) B-ALL cell lines (Fig. S1F). Here, IKZF1 is linked to precursor B-cell acute lymphoblastic leukemia.