Large-scale genomic studies have shown that most B-ALL subtypes harbor alterations in genes encoding hematopoietic transcription factors (TFs) or their regulators, including PAX5, ETV6, IKZF1, and RUNX1, highlighting the central role of TF dysfunction in leukemogenesis [57]. Here, IKZF1 is linked to precursor B-cell acute lymphoblastic leukemia.