IKZF1 and precursor B-cell acute lymphoblastic leukemia: Building on previous work demonstrating that IKAROS assembles lineage-specific 3D chromatin architecture in pre-B cells, including long-range enhancer to promoter interactions and the formation of superTADs that span TAD boundaries to organize regulatory units [27, 28], our study shows that re-expression of IKAROS in B-ALL cells partially reinstates this higher-order organization.