CCDC26, a long noncoding RNA located within the ~2 Mb MYC locus and frequently amplified in leukemia [49], has been shown to regulate acute myeloid leukemia cell proliferation through KIT signaling and to influence erythroid differentiation via FOG-2–mediated transcriptional control of globin genes [50, 51]. The gene discussed is CCDC26; the disease is leukemia.