Concordantly, CST reduced expression of CD68, GFAP, IL-6, TNF-α, CXCL1, and CXCL10, extending its known peripheral anti-inflammatory actions 20,38 to the central nervous system and establishing CST as a regulator of neuroimmune homeostasis in Tauopathy. This evidence concerns the gene CXCL10 and tauopathy.