Other primary Tauopathies, such as corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), display region-specific accumulation of pathological Tau isoforms and share overlapping clinical features, including motor dysfunction, executive deficits, and neuronal loss in affected cortical and subcortical regions 5. The gene discussed is MAPT; the disease is corticobasal degeneration disorder.