Other primary Tauopathies, such as corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), display region-specific accumulation of pathological Tau isoforms and share overlapping clinical features, including motor dysfunction, executive deficits, and neuronal loss in affected cortical and subcortical regions 5. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.