To search for TME factors responsible for this lineage transition, we analyzed histologic sections from wild-type normal prostate tissue, as well as PRAD and NEPC regions from the PtRP (Pten−/−, Rb1−/−, Trp53−/−, Pb-Cre) genetically engineered mouse model (GEMM) (17). Here, RB1 is linked to prostate adenocarcinoma.