EBF3 and hypotonia, ataxia, and delayed development syndrome: Loss-of-function mutations in the unc-3 human ortholog, EBF3, cause Hypotonia, Ataxia, and Delayed Development Syndrome (HADDS), also known as EBF3 Syndrome, a recently identified neurodevelopmental disorder characterized by motor dysfunction, muscle hypotonia, intellectual disability, and autism spectrum features38–45.