In addition to its role in activating NF-κB, a critical gene regulator involved in cell survival, viral replication, and pathological processes such as autoimmune diseases, various types of cancer, and inflammation, TNF has also been shown to mediate both anti-apoptotic and pro-apoptotic signals and can even trigger necroptosis, a type of pro-inflammatory cell death [11]. This evidence concerns the gene NFKB1 and cancer.