After observing that homozygous Mbp 3’ UTR KO mice have tremors (Fig. 3F and 3G), defects in Mbp mRNA transport and local translation (Fig. 4), and hypomyelination across multiple brain regions (Fig. 5), we asked whether replacing the Mbp 3’UTR results in other functional and behavioral consequences in vivo. The gene discussed is MBP; the disease is Tremor.