Two LOH events also show significant associations with SD trajectory NS-LUAD tumours: loss of 6q (encompassing ARID1B, ESR1, and RSPO3; OR for enrichment in SD = 2.2, FDR = 0.030)—and loss of 3p (harbouring four tumour suppressors26–29: SETD2, TGFBR2, BAP1, and ROBO2; OR for enrichment in SD = 2.0, FDR = 0.049). Here, RSPO3 is linked to neoplasm.