EGFR and neoplasm: In accordance with this, EGFR mutations are the events most significantly associated with NSD trajectories across all LUAD samples (Fig. 3a, OR for enrichment in NSD = 88.9, FDR = 2.2×10−54), and found exclusively in NSD tumours when considering only NS-LUAD (Fig. 3b, FDR = 1.5×10−26).