Alcohol‐induced hepatic inflammation involves a variety of complex mechanisms, the core mechanism of which lies in LPS translocation (Shuwen and Kefeng 2022; Chen et al. 2022; An et al. 2022) and its triggered hyperactivation of the TLR4/NF‐κB/NLRP3 inflammatory axis. The gene discussed is NLRP3; the disease is inflammation.