Alcohol‐induced hepatic inflammation involves a variety of complex mechanisms, the core mechanism of which lies in LPS translocation (Shuwen and Kefeng 2022; Chen et al. 2022; An et al. 2022) and its triggered hyperactivation of the TLR4/NF‐κB/NLRP3 inflammatory axis. This evidence concerns the gene NFKB1 and inflammation.