The goal of this study was to examine how the combination of Curcuma zedoaria (zedoary) and Curcuma longa (turmeric) affected things on the kidneys of rats with acute kidney injury (AKI) from cisplatin by assessing the reduction of levels of cysteine-aspartic acid protease 3 (Caspase-3), kidney injury molecule-1 (KIM-1), and tumor necrosis factor-alpha (TNF-α) in renal tissue. The gene discussed is HAVCR1; the disease is acute kidney injury.