PRNP and Creutzfeldt Jacob disease: Creutzfeldt-Jakob disease (CJD) is one of the main prion diseases, an always fatal neurodegenerative disorder.1 The common pathological process is characterized by the conversion of the normal cellular prion protein (PrPc) to an insoluble anomalous form (PrPSc) that accumulates progressively in the brain, sometimes forming extracellular amyloid plaques.2