PIK3CA and cancer: Numerous studies and reviews have elucidated PI3K/AKT-mediated mechanisms in diseases such as cancer (Hao et al., 2025; Hashemi et al., 2023; Yu X et al., 2022), inflammatory conditions (Chen et al. 201b; Sun F. et al., 2020), neurological disorders (Guo et al., 2024), and fibrotic diseases (Wang J. et al., 2022).