Nonetheless, specific lncRNAs such as FPASL and LOC344887 have been shown to negatively regulate PI3K/AKT, inhibiting hypertrophic scar fibroblasts (HSFs) proliferation and modulating ECM in IPF, respectively (Liu G. et al., 2021; Ma et al., 2022). Here, PIK3CA is linked to idiopathic pulmonary fibrosis.