Examination of circRNA ceRNA networks in myocardial fibrosis further elucidates that differentially expressed circRNAs modulate CFs proliferation and differentiation by regulating pathways such as PI3K/AKT and TGF-β, underscoring their essential role in the progression of cardiac fibrosis (Gu et al., 2020). The gene discussed is AKT1; the disease is Myocardial fibrosis.