Together, these results suggest that although VAMP7 exhibits a characteristic ‘decrease‐then‐increase’ pattern during HPV16‐associated lesion progression, its overall upregulation in HPV18+ and HPV− CC indicates that VAMP7 may contribute broadly to CC development, potentially acting at the interface between HPV‐driven molecular alterations and tumour progression. The gene discussed is VAMP7; the disease is neoplasm.