In the present study, we found that ANGPTL2 deficiency attenuated kidney fibrosis and reduced the expression of fibrosis‐related genes, suggesting that ANGPTL2 promotes fibrotic remodeling in the kidney under HFD‐fed conditions, consistent with previous reports demonstrating that ANGPTL2 exacerbates renal fibrosis in a mouse unilateral ureteral obstruction model (Morinaga et al. 2016). This evidence concerns the gene ANGPTL2 and Ureteral obstruction.