Furthermore, qRT‐PCR analysis showed significantly lower transcript levels of Nppa, a marker of heart failure, in the hearts of HFD‐fed Angptl2−/− mice compared to HFD‐fed WT mice; however, expression of other heart failure markers (Nppb and Myh7) and fibrosis markers (Col1a1 and Ctgf) were comparable between genotypes (Figure 4h,i). This evidence concerns the gene COL1A1 and heart failure.