Cluster 2 (Figure 3B) captured the metabolic decline, with loss of Cystathionine beta‐synthase (CBS), a critical enzyme in sulfur amino acid metabolism and linked to oxidative stress and chronic kidney disease (CKD) (Hamidizad et al. 2023), and Sirt3, a regulator of mitochondrial ROS through Superoxide dismutase (SOD2) (Chen et al. 2011). Here, SIRT3 is linked to chronic kidney disease.