TRIM28 and neoplasm: When mice bearing NPp53T tumors with Trim28 deletion were castrated, the tumors developed castration-resistance, resulting in a median survival of 134 days after tumor induction, which was significantly shorter than the survival for castrated mice with NPp53 tumors (Fig. 2A, B), and similar to our previously reported median survival of 122 days for hormonally intact NPp53T tumors [18].