In contrast, Rb1 treatment in IRI-induced AKI mice resulted in significant improvement in renal function, evidenced by marked reductions in BUN and CREA (Fig. 2B, C), along with substantial histological preservation, including decreased brush border loss, attenuated tubular dilation, diminished protein cast formation, and reduced necrotic changes (Fig. 2D, E). The gene discussed is RB1; the disease is acute kidney injury.