In animal and cellular models, NXSB could up-regulate Foxp3 while downregulating RORγt and STAT3, suppress inflammasome and NF-κB-related pathways, and attenuate inflammation, leading to increased platelet counts and restored Treg function in ITP mice[171]. The gene discussed is NFKB1; the disease is autoimmune thrombocytopenic purpura.