TPO and autoimmune thrombocytopenic purpura: In murine models of ITP or thrombocytopenia, total flavonoids from Sarcandrae Herba could upregulate the TPO-c-Mpl and SDF-1-CXCR4 axes within the bone marrow microenvironment, promote megakaryocyte differentiation and maturation, and increase peripheral platelet count [77].