TNF and autoimmune thrombocytopenic purpura: In the treatment of ITP, key target genes of Spatholobus suberectus primarily acts on key target genes such as tumor necrosis factor (TNF), IL-6, IL-1β, STAT3, chemokine ligand 2 (CCL2), CXC ligand 8 (CXCL8, also known as IL-8), and chromosome 1 genes [86].