IL6 and autoimmune thrombocytopenic purpura: Concerning its role of maintaining immune homeostasis, it can restore the Treg/Th17 balance and hinder inflammatory or differentiation-related signaling pathways such as PI3K-Akt-mTOR and Notch, and alleviate ITP-like immune dysregulation, thereby reducing proinflammatory cytokines (e.g., IL-6 and IL-17A) and improving the peripheral immune microenvironment.