MAPT and central precocious puberty: Furthermore, out of 13 DE miRNAs common to MAPI vs HC and MAPT vs HC comparisons in CPP, four (bta-miR-484, bta-miR-21-5p, bta-miR-2285b and bta-miR-148a) had up-regulated expression in MAPI vs HC while five (bta-miR-125a, bta-miR-193a-5p, bta-miR-193b, bta-miR-382 and bta-miR-125b) had down-regulated expression in MAPT vs HC, implying that even the few DE miRNAs common to these phenotypes are expressed differently and so too will impact biological processes differently., supporting a role of miRNA in the ability of the host to tolerate the presence of MAP.