BDNF and cocaine dependence: KEGG pathway and GO molecular function analyses (Table 1) of the differentially expressed proteins indicated enrichment in terms such as Cocaine addiction, Amphetamine addiction, Neurotrophin Binding, Monoamine Transmembrane Transporter Activity and Transcription Coactivator Binding, among others (see Files S2A and S2B for the top 10 significant terms in males and females).