The reductions observed in IFN-γ and MMP-1 due to VIDS were not statistically significant (-6.7%; p = 0.69 and -5.4%; p = 0.23, respectively).<h4>Conclusion</h4>In CRC patients with low vitamin D status, VIDS reduces serum IL-6, a pro-inflammatory biomarker associated with poor prognosis. This evidence concerns the gene MMP1 and colorectal carcinoma.