These autism-associated genes reiterate the diversity of the biological pathways connected to PLR amplitude highlighted in the GO analysis, with gene functions ranging from immunity (CARD11)40, to metabolic pathways and circadian regulation (CSNK2B)40,43, to glycoprotein production (GALNT10)40, and calcium signalling pathways (CACNA1D)40. Here, CARD11 is linked to autism.