Within the Josephin domain-containing Deubiquitinases, ataxin-3 (ATXN3) is the most well-characterized and exhibits tissue-specific duality: it acts as an oncogene in breast and prostate cancers but as a tumor suppressor in gastric and colorectal cancers[22–26] This functional ambiguity underscores the importance of investigating its role in cervical cancer subtypes. The gene discussed is ATXN3; the disease is colorectal cancer.