LRP1 and coronary artery disorder: Integrating RNA-array datasets of senescent human coronary arterial endothelial cells (HCAECs) and aortic smooth muscle cells (HASMCs) as well as genome-wide association data for coronary artery disease (CAD) identified that CST3 is functionally aided vascular aging, and COL4A1-ITGA1 and LPL-LRP1 pathways are related to the key processes of vascular aging and atherosclerosis development [56].