NLRP3 and hypertensive disorder: The molecular signals of hypertension such as damage-associated molecular pattern (DAMPs), pathogen associated molecular patterns (PAMPs), activate Toll-like receptors(TLRs) and nucleotide-binding and oligomerization domain (NOD)-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome in pro-inflammatory macrophage(M1 macrophages) and DCs, respectively to drive the inflammatory process [59, 60].