NOX4 and hypertensive disorder: The function of bone marrow microvascular in hypertension may be associated with some classical signaling pathways, such as SFRP5-MAPK14 and SFRP5-Wnt/β-catenin pathways, FKBP5/NF-κB axis, TGF-β1–NOX4 axis and S6K1-Arg2 axis, previous studies also imply the role of Sirt1, Sirt4 and ANXA1 in the progress (Fig. 3).