In addition to calcium overload, most PD-related genes, such as a-synuclein, PINK1, Parkin, LRRK2, DJ-1, GBA and ATPA13A2, are involved in mitochondrial function and autophagy-lysosome pathways, and mutations in these genes cause diverse alterations related to the progression of PD [12, 13]. The gene discussed is PRKN; the disease is Parkinson disease.