A study that analyzed tissue microarrays from 11,152 PCas showed that YBX1 was detectable in 86.3% of PCa, absent or weak relative to normal epithelium, and that YBX1 nuclear staining was strongly associated with poor patient prognosis, tumor stage, Gleason score, and lymph node metastasis [58]. The gene discussed is YBX1; the disease is neoplasm.