Moreover, validation through PCa-derived exosomes demonstrated functional consistency of this molecular axis: after treating hFOB cells with exosomes from RWPE-1, C4-2B-sh-NC, and C4-2B-sh-SNHG1 cell lines, both RNA and protein expression levels of MMP16 correlated positively with exosomal SNHG1 content. Here, SNHG1 is linked to posterior cortical atrophy.