To investigate the specific mechanism by which YBX1 influences ccRCC glycolysis via LDHA, we first used a dual-luciferase reporter assay to screen potential signaling pathways that might be affected by the overexpression of YBX1 and LDHA, including the WNT, NF-κB, NFAT, GAS, STAT3, and P53 pathways. This evidence concerns the gene YBX1 and nonpapillary renal cell carcinoma.