SLC6A6 and Osteopenia: Our analysis of 16 week old TauT−/− femur bone morphological structure using micro-computed tomography (micro-CT) revealed a 5–10% decrease in both cortical and trabecular thickness, a 11–21% increase in trabecular spacing, and a ~30% decrease in trabecular BV/TV as compared to controls, indicating an osteopenia-like phenotype [39] (Fig. 4c–h).