BDNF and central nervous system cancer: Conversely, neuronal activity promotes glioma progression through electrochemical communication via neuron-glioma synapses, potassium-induced currents, and the secretion of growth factors such as Neuroligin 3, Insulin-like Growth Factor 1, and Brain-derived Neurotrophic Factor (Venkatesh et al., 2015, Pan et al., Jun 2021, Venkatesh et al., 2017, Venkataramani et al., Sep 2019, Chen et al., Jun 2022).