Conversely, neuronal activity promotes glioma progression through electrochemical communication via neuron-glioma synapses, potassium-induced currents, and the secretion of growth factors such as Neuroligin 3, Insulin-like Growth Factor 1, and Brain-derived Neurotrophic Factor (Venkatesh et al., 2015, Pan et al., Jun 2021, Venkatesh et al., 2017, Venkataramani et al., Sep 2019, Chen et al., Jun 2022). This evidence concerns the gene IGF1 and central nervous system cancer.