This perspective aligns with recent advances in cancer neuroscience, which demonstrate that glioma cells secrete glutamate, Glypican-3, and Thrombospondin-1 to induce neuronal hyperexcitability and functional remodeling of neural circuits (Buckingham et al., 2011, Yu et al., Feb 2020, Krishna et al., May 2023). Here, THBS1 is linked to central nervous system cancer.