This perspective aligns with recent advances in cancer neuroscience, which demonstrate that glioma cells secrete glutamate, Glypican-3, and Thrombospondin-1 to induce neuronal hyperexcitability and functional remodeling of neural circuits (Buckingham et al., 2011, Yu et al., Feb 2020, Krishna et al., May 2023). The gene discussed is GPC3; the disease is cancer.