Furthermore, the observation of subtle ectodermal-associated signs in one proband, specifically preauricular pits and dry skin, parallels features reported in rare syndromic LRP6 cases, including those with oligodontia and orofacial clefts, eg, as discussed by Previdi et al13 who described LRP6 variants associated with broader systemic involvement. The gene discussed is LRP6; the disease is orofacial cleft.