Notably, LRP6-related tooth agenesis exhibited variable expressivity, even within families,32,37 and could involve digenic interactions, for instance with WNT10A. 36Functional studies8,30 and 3D modeling35,38 support the role of LRP6 in Wnt signalling disruption, underscoring its critical function in dental development. Here, LRP6 is linked to tooth agenesis.